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Related Experiment Videos

Layers of exercise hyperpnea: modulation and plasticity.

Gordon S Mitchell1, Tony G Babb

  • 1Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA. mitchell@svm.vetmed.wisc.edu

Respiratory Physiology & Neurobiology
|March 15, 2006
PubMed
Summary
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The exercise hyperpnea, or ventilatory response to exercise, involves feedforward and feedback mechanisms. This review explores how modulation and plasticity allow this response to adapt to changing physiological conditions.

Area of Science:

  • Physiology
  • Respiratory Control
  • Exercise Science

Background:

  • The mechanisms of exercise hyperpnea (ventilatory response to exercise) are not fully understood.
  • Regulation involves feedforward stimuli and chemoreceptor feedback, but adaptive strategies may also play a role.

Purpose of the Study:

  • To review evidence for modulation and plasticity in the exercise ventilatory response.
  • To explore the relevance of these adaptive mechanisms to human physiology.

Main Methods:

  • Review of existing literature on exercise hyperpnea.
  • Examination of data from a goat model to illustrate modulation and plasticity.
  • Consideration of human relevance for identified mechanisms.

Main Results:

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  • Evidence suggests short-term and long-term modulation of the exercise ventilatory response exists.
  • Plasticity in respiratory control is a recently recognized property with implications for exercise.

Conclusions:

  • Modulation and plasticity allow the exercise ventilatory response to adapt to various physiological conditions.
  • Understanding these adaptive mechanisms is crucial for human respiratory health during exercise throughout life.