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RNA Interference

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RNA Interference

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Related Experiment Video

Updated: May 12, 2026

Chromatin Isolation by RNA Purification (ChIRP)

Chromatin Isolation by RNA Purification (ChIRP)

Published on: March 25, 2012

A long-distance relationship between RNAi and Polycomb.

Elissa P Lei¹, Victor G Corces

¹Department of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA.

|March 15, 2006

Summary

This summary is machine-generated.

The RNA interference (RNAi) machinery is essential for physical interactions between chromosomes. This suggests RNAi plays a role in higher-order nuclear organization and gene regulation.

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Chromatin Isolation by RNA Purification (ChIRP)

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Published on: March 25, 2012

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RNA-Associated Chromatin DNA-DNA Interaction Method

RNA-Associated Chromatin DNA-DNA Interaction Method

Published on: April 30, 2026

Area of Science:

Molecular Biology
Genetics
Epigenetics

Background:

RNA interference (RNAi) pathways mediate sequence-specific transcriptional gene silencing at the chromatin level.
The Polycomb repressive complex (PRC) is involved in gene silencing and chromatin regulation.

Purpose of the Study:

To investigate the role of the RNAi machinery in chromosome interactions.
To explore the connection between RNAi, PRC, and nuclear organization.

Main Methods:

Utilized RNA interference (RNAi) pathways.
Studied the Polycomb repressive complex (PRC).
Investigated physical interactions between chromosomes.

Main Results:

The RNAi machinery is required for long-distance physical interactions between chromosomes.
These interactions are mediated by the Polycomb repressive complex (PRC).

Conclusions:

The RNAi machinery is implicated in regulating higher-order nuclear organization.
RNAi may influence genome structure and function beyond gene silencing.