Related Experiment Video
Updated: Aug 10, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
Therapy of invasive bladder cancer
1Department of Urology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. cdinney@mdanderson.org
Abstract:
Effective treatment of invasive bladder cancer depends upon an understanding of the natural history of this disease and careful clinical staging. Radical cystectomy offers acceptable long-term survival for most individuals with organ-confined disease, but those with more advanced tumors or those associated with adverse features may benefit from the addition of neoadjuvant chemotherapy.
Related Concept Videos
Urinary Tract Calculi VI: Surgical Management
Kidney Transplant II: Surgical Procedure
Tumor Immunotherapy
Urinary Tract Calculi V: Nursing Management
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...