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Updated: Aug 10, 2026

In Vitro Myelination of Peripheral Axons in a Coculture of Rat Dorsal Root Ganglion Explants and Schwann Cells
Published on: February 10, 2023
[Reversible peripheral neuropathy induced by vitamin B12 deficiency]
G Sakly1, O Hellara, A Trabelsi
1Service d'explorations fonctionnelles du système nerveux, hôpital universitaire Sahloul, 4054, Sousse. saklyg@yahoo.fr
Objective:
To describe an electroclinical presentation of a peripheral neuropathy in a patient who suffered from vitamin B12 deficiency.
Patient And Methods:
We report the case of a 56-year-old man who, 17 years after a subtotal gastrectomy, presented with a diffuse sensory-motor demyelinating peripheral neuropathy with multifocal alteration of conduction confirmed by electromyography. Its causal relationship with vitamin B12 deficiency was biologically demonstrated. This neuropathy improved within a few days after intramuscular hydroxocobalamin treatment. Both clinical and electrophysiological signs had totally disappeared 3 months later on.
Conclusion:
This observation demonstrates that, in spite of its poor outcome reported by several authors, peripheral neuropathy induced by vitamin B12 deficiency can recover completely with substitutive treatment.
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