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Diabetes--a man made disease.

R B Elliott1

  • 1Living Cell Technologies Limited, 19 Laureston Avenue, Papatoetoe, Auckland 1730, New Zealand. relliott@lctglobal.com

Medical Hypotheses
|March 15, 2006
PubMed
Summary
This summary is machine-generated.

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Modern environmental changes, particularly in food processing, may be driving the rise in diabetes. Processed foods contain agents like glycation products and ascorbic acid that can induce diabetes through plausible mechanisms.

Area of Science:

  • Environmental Science
  • Endocrinology
  • Food Science

Background:

  • Global incidence of both type 1 and type 2 diabetes has increased significantly in recent decades.
  • This rise suggests a link to modern environmental factors rather than solely genetic predispositions.

Purpose of the Study:

  • To identify potential environmental agents responsible for the recent increase in diabetes.
  • To evaluate candidate agents based on their environmental prevalence, diabetogenic effects in animal models, and plausible mechanisms.

Main Methods:

  • Literature review and hypothesis formulation based on established criteria for environmental agents.
  • Analysis of modern food processing techniques and common additives for potential diabetogenic compounds.
  • Examination of biochemical pathways linking food components to diabetes development.

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Main Results:

  • Modern food processing generates glycation end products, oxidized ascorbic acid, and lipoic acid, all potential diabetogenic agents.
  • Infant formula exhibits particularly high levels of glycation products and added ascorbic acid.
  • A1 beta-casein derived casomorphin, when glycated, may exert adverse immune effects contributing to diabetes.

Conclusions:

  • Food processing and additives represent a plausible man-made environmental cause for the increasing prevalence of diabetes.
  • This hypothesis is consistent with the observed rise in diabetes and the identified properties of processed foods.
  • Other environmental agents meeting the specified criteria are not excluded as contributing factors.