A profile of acute poisoning at Mangalore (South India)

Bhoopendra Singh1, B Unnikrishnan

  • 1Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal, Udupi, Karanataka 576104, India. drbsingh2003@yahoo.com

Abstract

Insights

Acute poisoning cases in South India were analyzed, revealing agrochemical pesticides as the leading cause. Organophosphate and aluminum phosphide poisonings require urgent prevention and treatment strategies.

Area of Science:

  • Toxicology
  • Public Health
  • Epidemiology

Background:

  • Characterizing poisoning cases admitted to Government Wenlock Hospital in Mangalore, India.
  • Analyzing trends in acute poisoning admissions at a major teaching hospital.

Purpose of the Study:

  • To characterize poisoning cases admitted to Government Wenlock Hospital.
  • To identify common poisoning agents and outcomes in South India.

Main Methods:

  • Retrospective evaluation of emergency department admissions from January 2001 to May 2003.
  • Data collection from hospital medical records, including socio-demographics, agents, route of intake, and admission time.
  • Analysis of 325 acute poisoning cases out of 33,207 total emergency admissions.

Main Results:

  • Acute poisoning constituted 1% of emergency admissions (325 cases).
  • Males (70%) predominated, with the 21-30 age group most affected (36%).
  • Intentional poisonings (72%) were more common than unintentional (27%).
  • Agrochemical pesticides (49%) were the primary agents, followed by drugs (17%) and alcohols (13%).
  • Mortality rate was 15% (48 deaths), with organophosphate pesticides (65%) and aluminum phosphide (15%) being the main causes.
  • Organophosphate pesticides and aluminum phosphide were responsible for most fatalities.

Conclusions:

  • Agrochemical pesticides, particularly organophosphates and aluminum phosphide, are significant causes of acute poisoning and mortality in South India.
  • Prevention and treatment strategies for organophosphate and aluminum phosphide poisoning should be prioritized for the indigenous population of the Dakshina Kannada district.
  • Public health interventions targeting pesticide use and management are crucial in reducing poisoning incidence and mortality.

Related Concept Videos

Antidotes01:17

Antidotes

Antidotes are medicinal substances used to counteract the harmful effects of toxins or drugs in the body. They function in various ways, each uniquely designed to combat specific toxic compounds.
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...