Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Type 1 diabetes.

Denis Daneman1

  • 1Division of Endocrinology, Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada M5G 1X8. denis.daneman@sickkids.ca

Lancet (London, England)
|March 15, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of statins and ACE inhibitors on the metabolome in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT) cohort.

Scientific reports·2026
Same author

Daneman Syndrome Revisited.

The Journal of pediatrics·2026
Same author

Socioeconomic representativeness of Australian, Canadian and British cohorts from the paediatric diabetes AdDIT study: comparisons to regional and national data.

BMC medicine·2023
Same author

INSPIRED but Tired: How Medical Faculty's Job Demands and Resources Lead to Engagement, Work-Life Conflict, and Burnout.

Frontiers in psychology·2021
Same author

The Ongoing Transmutation of Type 1 Diabetes: Disparities in Care and Outcomes.

Canadian journal of diabetes·2021
Same author

A newborn with a massive goiter.

Paediatrics & child health·2020
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Type 1 diabetes, a growing global health concern, requires comprehensive management focusing on insulin, glucose monitoring, and complication screening. Despite advances, preventing and treating this autoimmune disorder and its complications remain significant challenges.

Area of Science:

  • Endocrinology
  • Immunology
  • Genetics

Background:

  • Type 1 diabetes (T1D) represents 5-10% of all diabetes cases, with increasing global incidence and significant short- and long-term health consequences.
  • While T1D has a strong genetic basis, particularly linked to the HLA complex, the specific triggers for clinical onset are not fully understood.

Purpose of the Study:

  • To review the current understanding of Type 1 diabetes, including its genetic factors, management strategies, and associated complications.
  • To highlight recent advancements in treatment and persistent challenges in prevention and management.

Main Methods:

  • Literature review of current research on Type 1 diabetes epidemiology, genetics, clinical management, and complications.
  • Synthesis of information on established and emerging therapeutic approaches.

Related Experiment Videos

Main Results:

  • Type 1 diabetes management necessitates a multidisciplinary approach, integrating insulin therapy, blood glucose monitoring, diet, and screening for comorbidities and complications.
  • Microvascular and macrovascular diseases are the primary causes of morbidity and mortality in T1D patients.
  • Newer treatments have improved glycemic control and reduced complication risks.

Conclusions:

  • Effective management of Type 1 diabetes involves continuous attention to multiple health aspects and screening for complications.
  • Despite treatment improvements, significant challenges persist in preventing and managing Type 1 diabetes and its associated long-term complications.