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Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
Published on: May 19, 2020
Using registry data to evaluate the 2004 pneumococcal conjugate vaccine shortage
Norma J Allred1, John M Stevenson, Maureen Kolasa
1National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. nallred@cdc.gov
American Journal of Preventive Medicine
|March 15, 2006
Summary
During a vaccine shortage, providers followed recommendations to delay pneumococcal conjugate vaccine (PCV7) doses for children. Immunization registry data showed temporary drops in PCV7 coverage, highlighting the registry
Area of Science:
- Public Health
- Vaccinology
- Epidemiology
Background:
- A pneumococcal conjugate vaccine (PCV7) shortage occurred from December 2003 to September 2004.
- Recommendations were issued to delay PCV7 doses for healthy children to prioritize high-risk infants.
- The Michigan Child Immunization Registry (MCIR) database was utilized to assess PCV7 coverage changes.
Purpose of the Study:
- To evaluate changes in PCV7 vaccination coverage during a vaccine shortage.
- To assess provider compliance with recommendations for altering vaccine administration schedules.
- To determine the utility of immunization registries in monitoring vaccine coverage trends during shortages.
Main Methods:
- Analysis of vaccination and demographic data for 420,733 children born between September 2001 and August 2004 from the MCIR.
- Key outcome measures included the proportion of children receiving the third PCV7 dose by 7 months and the fourth dose by 16 months.
- Coverage for measles, mumps, and rubella (MMR) and diphtheria, tetanus, and acellular pertussis (DTaP) vaccines served as comparative benchmarks.
Main Results:
- PCV7 coverage for the third dose decreased from 29% to 11%, and for the fourth dose from 27% to 22% following recommendations to defer administration.
- Coverage for DTaP and MMR remained stable, indicating the observed PCV7 changes were specific to the shortage.
- PCV7 coverage returned to near pre-shortage levels after recommendations to resume the normal vaccination schedule, with similar trends in public and private sectors.
Conclusions:
- Immunization registries are valuable tools for tracking vaccination coverage during vaccine shortages.
- Healthcare providers demonstrated compliance with public health recommendations to modify vaccine administration during the PCV7 shortage.
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