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Related Experiment Videos

Focal spinal arachnoiditis increases subarachnoid space pressure: a computational study.

L E Bilston1, D F Fletcher, M A Stoodley

  • 1Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, NSW 2031, Australia.

Clinical Biomechanics (Bristol, Avon)
|March 15, 2006
PubMed
Summary

Scar tissue (arachnoiditis) after spinal cord injury may increase fluid pressure in the spinal cord. This pressure can drive fluid into the spinal cord, potentially causing syringomyelia (syrinx formation).

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Fluid Dynamics

Background:

  • Post-traumatic syringomyelia affects up to 28% of spinal cord injury patients, leading to neurological decline.
  • Current treatments for syringomyelia are often ineffective.
  • Arachnoiditis, localized scar tissue in the subarachnoid space, is implicated in syrinx development.

Purpose of the Study:

  • To test if pressure pulses in the subarachnoid space are amplified near arachnoiditis.
  • To investigate if these amplified pressures contribute to fluid entering the spinal cord and forming syrinxes.

Main Methods:

  • Developed a computational fluid dynamics model of the subarachnoid space.
  • Simulated normal conditions and the presence of arachnoiditis modeled as a porous obstruction.

Related Experiment Videos

  • Estimated cerebrospinal fluid flow using MRI data.

    • Main Results:

    • Peak fluid pressures were significantly higher adjacent to the simulated arachnoiditis obstruction.
    • The magnitude of pressure elevation strongly correlated with the obstruction's permeability.
    • Systolic pressure peaks were accentuated in the presence of arachnoiditis.

    Conclusions:

    • Elevated subarachnoid pressure due to arachnoiditis may drive cerebrospinal fluid into the spinal cord, promoting syringomyelia.
    • Inhibiting arachnoiditis or reducing systolic pressure peaks could be therapeutic strategies.
    • Further research into managing arachnoiditis is warranted for syringomyelia treatment and prevention.