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Systemic nitric oxide augmentation leads to a rapid decrease of the bladder outlet resistance in healthy men
Michael Müntener1, Brigitte Schurch, Björn Wefer
1Department of Urology, University Hospital, Zurich, Switzerland. muntener@jhmi.edu
European Urology
|March 15, 2006
Summary
Systemic nitric oxide (NO) augmentation rapidly reduces bladder outlet resistance in men. This suggests the NO-cGMP pathway is a potential therapeutic target for lower urinary tract symptoms.
Area of Science:
- Urology
- Pharmacology
Background:
- Bladder outlet resistance is a key factor in lower urinary tract symptoms.
- Nitric oxide (NO) plays a role in smooth muscle relaxation, potentially affecting bladder function.
Purpose of the Study:
- To investigate the immediate impact of systemic NO enhancement on bladder outlet resistance in healthy males.
- To assess the effect of NO augmentation on urodynamic parameters.
Main Methods:
- Eleven healthy males underwent baseline urodynamic pressure-flow studies.
- Subjects received sublingual isosorbide dinitrate (a NO donor).
- A second pressure-flow study was conducted after 20 minutes to compare parameters.
Main Results:
- The mean average flow rate increased significantly post-NO administration (16.7 to 20.2 ml/s).
- Average detrusor pressure during micturition decreased (57 to 52 cm H2O).
- Detrusor pressure at maximum flow rate also decreased (60 to 52 cm H2O).
Conclusions:
- Systemic NO augmentation can rapidly decrease functional bladder outlet resistance in men.
- The NO-cGMP pathway presents a promising therapeutic target for managing lower urinary tract symptoms.