Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[DLST as a method for detecting TS-1-induced allergy].

Rumi Kawabata1, Masahiro Koida, Shohei Kanie

  • 1Drug Safety Lab., Taiho Pharmaceutical Co., Ltd.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|March 15, 2006
PubMed
Summary

The drug-induced lymphocyte stimulation test (DLST) may yield false positives for TS-1 anticancer drug allergies. Healthy volunteers showed positive DLST results, suggesting caution when interpreting allergy tests for patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KK2845, a PBD dimer-containing antibody-drug conjugate targeting TIM-3-expressing AML.

Leukemia·2025
Same author

TAS0612, a Novel RSK, AKT, and S6K Inhibitor, Exhibits Antitumor Effects in Preclinical Tumor Models.

Molecular cancer therapeutics·2023
Same author

Evaluation of a Novel Combination Therapy, Based on Trifluridine/Tipiracil and Fruquintinib, against Colorectal Cancer.

Chemotherapy·2023
Same author

Derivatization-assisted immunoassays: application for group-specific detection of potent methamphetamine and amphetamine enantiomers.

Analytical methods : advancing methods and applications·2022
Same author

Acquired resistance to trastuzumab/pertuzumab or to T-DM1 in vivo can be overcome by HER2 kinase inhibition with TAS0728.

Cancer science·2020
Same author

Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats.

The Journal of toxicological sciences·2020

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Context:

  • Anticancer drugs like TS-1, a 5-FU derivative, can cause allergic adverse events.
  • The drug-induced lymphocyte stimulation test (DLST) is used to identify potential drug allergies.
  • Accurate allergy assessment is crucial for patient safety during cancer treatment.

Purpose:

  • To evaluate the reliability of the DLST for detecting TS-1-induced allergies.
  • To establish reference data for DLST results in healthy individuals.
  • To investigate potential causes of false-positive DLST results.

Summary:

  • A study on 20 healthy volunteers found 6 positive DLST responses to TS-1.
  • This suggests the DLST may produce false positives due to thymidine incorporation via salvage pathways.

Related Experiment Videos

  • Inhibition of DNA de novo synthesis by 5-FU derivatives can influence DLST outcomes.

    • Impact:

    • The findings indicate that a positive DLST for TS-1 may not always signify a true allergy.
    • Clinicians should use DLST results cautiously and in conjunction with other clinical evaluations.
    • This research highlights the need for careful assessment of drug-induced allergies in patients undergoing TS-1 treatment.