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Related Experiment Videos

Resistin.

Philip G McTernan1, Christine M Kusminski, Sudhesh Kumar

  • 1Diabetes and Metabolism Research Laboratory, Clinical Sciences Research Institute, UHCW Trust, Walsgrave, Coventry, UK.

Current Opinion in Lipidology
|March 15, 2006
PubMed
Summary
This summary is machine-generated.

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Resistin, an adipocytokine, influences glucose homeostasis and insulin signaling. Recent findings reveal its pro-inflammatory role and multimeric structures impacting metabolism in humans and rodents.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Metabolic Research

Background:

  • Resistin is a 12.5 kDa polypeptide adipocytokine.
  • Its role in obesity-mediated insulin resistance and type 2 diabetes mellitus is debated.
  • Functionality in human glucose metabolism and insulin signaling requires further elucidation.

Purpose of the Study:

  • Summarize current knowledge on resistin.
  • Contextualize recent developments in resistin research.
  • Discuss controversial aspects of resistin's function.

Main Methods:

  • Literature review of resistin research.
  • Analysis of studies on resistin's role in glucose homeostasis.
  • Investigation of resistin's chemical properties and oligomerization.

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Main Results:

  • Resistin acts as a pro-inflammatory cytokine.
  • It may contribute to metabolic disease through direct metabolic effects and inflammation.
  • Homo-oligomerization of resistin influences its function.

Conclusions:

  • Higher molecular weight resistin structures identified in human and rodent serum.
  • Multimeric resistin impacts substrate metabolism by impairing insulin action, especially in the liver.
  • Resistin also affects insulin-independent pathways.