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Training effects in mice after long-term voluntary exercise.

Sara R Davidson1, Margaret Burnett, Laurie Hoffman-Goetz

  • 1Department of Health Studies and Gerontology, Faculty of Applied Health Studies, University of Waterloo, Waterloo, Ontario, Canada.

Medicine and Science in Sports and Exercise
|March 15, 2006
PubMed
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Long-term voluntary wheel running in mice significantly improved aerobic capacity and endurance. This study demonstrates that wheel running effectively induces aerobic training effects in female C57BL/6 mice.

Area of Science:

  • Exercise Physiology
  • Animal Models in Research
  • Sports Science

Background:

  • Mice are crucial animal models for studying exercise's impact on immunity, cancer, and aging.
  • Limited research exists on the long-term training effects of voluntary exercise in mice.

Purpose of the Study:

  • To investigate the physiological adaptations to long-term aerobic voluntary exercise in mice.
  • To quantify the training effects of voluntary wheel running over 16 weeks.

Main Methods:

  • Female C57BL/6 mice were divided into two groups: voluntary running wheel access (WR) and no running wheel access (NR) for 16 weeks.
  • Assessed were run-to-exhaustion times, maximal oxygen consumption (VO2peak), speed at VO2peak, and enzymatic activity (citrate synthase, succinate dehydrogenase, phosphofructokinase) in hindlimb muscles.

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Main Results:

  • Mice with running wheel access (WR) exhibited significantly longer run-to-exhaustion times and higher VO2peak compared to the control group (NR).
  • Increased citrate synthase and succinate dehydrogenase activity were observed in oxidative muscles (soleus, red gastrocnemius, plantaris) of WR mice.
  • Phosphofructokinase activity was elevated in the white gastrocnemius muscle of WR mice.

Conclusions:

  • Sixteen weeks of voluntary wheel running in female C57BL/6 mice induces significant aerobic training effects, including enhanced endurance and maximal oxygen uptake.
  • Wheel running is an effective exercise modality for inducing measurable aerobic adaptations in mice, suitable for long-term studies.