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Related Experiment Videos

Progression of kidney dysfunction in the community-dwelling elderly.

B R Hemmelgarn1, J Zhang, B J Manns

  • 1Department of Medicine, Division of Nephrology, University of Calgary, Calgary, Alberta, Canada. Brenda.hemmelgarn@calgaryhealthregion.ca

Kidney International
|March 15, 2006
PubMed
Summary

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Most elderly individuals show minimal kidney function decline over two years. Diabetes and lower kidney function are linked to faster decline, but interventions should consider the general stability in older adults.

Area of Science:

  • Nephrology
  • Geriatrics
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is common in older adults.
  • Limited data exists on kidney function decline in this demographic.
  • Understanding CKD progression is crucial for geriatric care.

Purpose of the Study:

  • To assess the rate of kidney dysfunction progression in a large community-based cohort of elderly subjects.
  • To identify factors associated with kidney function decline in older individuals.
  • To provide insights into the natural history of CKD in the elderly population.

Main Methods:

  • A cohort of 10,184 subjects aged 66+ years was analyzed.
  • Serum creatinine measurements from 2001-2003 were used to calculate estimated glomerular filtration rate (eGFR).

Related Experiment Videos

  • A mixed effects model analyzed eGFR decline per year, adjusting for age, gender, diabetes, and comorbidity.

    • Main Results:

    • The majority of elderly subjects experienced no or minimal eGFR decline over a median follow-up of 2.0 years.
    • Subjects with diabetes mellitus showed the fastest eGFR decline (2.1 ml/min/1.73 m²/year in women, 2.7 ml/min/1.73 m²/year in men).
    • Individuals with a mean eGFR < 30 ml/min/1.73 m² experienced the most significant decline, irrespective of diabetes status.

    Conclusions:

    • Most elderly individuals exhibit stable kidney function over a 2-year period.
    • Diabetes mellitus and severely reduced kidney function are key risk factors for accelerated CKD progression in the elderly.
    • Future strategies to slow CKD progression should account for these risk factors while acknowledging the general stability observed in the majority of older adults.