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Related Experiment Videos

Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device.

James H Prescott1, Sara Lipka, Samuel Baldwin

  • 1MicroCHIPS Inc., 6-B Preston Court, Bedford, Massachusetts 01730, USA.

Nature Biotechnology
|March 15, 2006
PubMed
Summary
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Controlled pulsatile release of leuprolide polypeptide was achieved using microchip implants in dogs over six months. This novel drug delivery system offers precise, telemetry-controlled dosing for therapeutic peptides and proteins.

Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Pharmacology

Background:

  • Peptide and protein therapeutics offer significant medical potential but face delivery challenges.
  • Implantable drug delivery systems are crucial for sustained and controlled release of biologics.
  • Microchip-based implants represent an advanced platform for precise drug administration.

Purpose of the Study:

  • To demonstrate controlled pulsatile release of a polypeptide drug using microchip implants.
  • To evaluate the long-term performance of microchip implants for drug delivery in a preclinical model.
  • To establish telemetry-controlled dosing capabilities for peptide-based therapeutics.

Main Methods:

  • Development of microchip implants with an array of discrete reservoirs.

Related Experiment Videos

  • Encapsulation of the polypeptide leuprolide within the microchip reservoirs.
  • In vivo study in dogs to assess drug release over a 6-month period.
  • Utilizing telemetry for remote control of drug dose delivery.

    • Main Results:

    • Successful controlled pulsatile release of leuprolide was achieved over 6 months.
    • Microchip implants demonstrated reliable and sustained drug delivery in a canine model.
    • Telemetry enabled precise and on-demand control over leuprolide dosage.

    Conclusions:

    • Microchip implants provide a viable platform for controlled pulsatile delivery of polypeptide drugs.
    • This technology enables long-term, telemetry-controlled administration of peptide therapeutics.
    • The findings support the therapeutic potential of advanced drug delivery systems for biologics.