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Related Experiment Videos

Circadian clocks are resounding in peripheral tissues.

Andrey A Ptitsyn1, Sanjin Zvonic, Steven A Conrad

  • 1Experimental Obesity Laboratory, Louisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.

Plos Computational Biology
|March 15, 2006
PubMed
Summary

Circadian rhythms influence gene expression in mouse liver and adipose tissues. Disturbances in these daily patterns may contribute to physiological disorders, highlighting the importance of circadian mechanisms in metabolism.

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Area of Science:

  • * Chronobiology and molecular biology.
  • * Genomics and systems biology.

Background:

  • * Circadian rhythms are fundamental biological processes present in most organisms.
  • * Disruptions in circadian gene expression can lead to physiological disorders.
  • * Previously, 5%-10% of genes in peripheral tissues were known to exhibit circadian expression.

Purpose of the Study:

  • * To comprehensively study circadian gene expression in multiple peripheral tissues.
  • * To identify and quantify genes with daily oscillatory patterns using various algorithmic approaches.

Main Methods:

  • * Large-scale microarray experiment analyzing daily cycles in murine white and brown adipose tissues and liver.
  • * Application of three distinct algorithmic methods to time series expression data.

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  • * Phase classification and computer simulations across multiple datasets.

    • Main Results:

    • * 7%-21% of active genes in mouse liver and adipose tissues exhibit daily oscillatory patterns.
    • * Analysis of external data suggests up to 50% of liver genes may be oscillatory.
    • * No clear boundary exists between oscillating and non-oscillating gene sets.

    Conclusions:

    • * Circadian gene expression is extensive in peripheral tissues, particularly liver and adipose tissue.
    • * Circadian mechanisms significantly influence metabolic pathways.
    • * Further research into circadian influence on metabolism and obesity is warranted.