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Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
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Nasopharyngeal colonization with Streptococcus pneumoniae in children infected with human immunodeficiency virus

Viviane C Cardoso1, Maria C Cervi, Otávio A L Cintra

  • 1Faculdade de Medicina de Ribeirão Preto, Hospital das Clínicas, São Paulo, SP, Brazil. vicuca@netsite.com.br

Jornal De Pediatria
|March 15, 2006
PubMed

Insights

Pneumococcus colonization in HIV-infected children is 28.6%, with 15.6% penicillin resistance. This prevalence is similar to healthy children, with no identified risk factors associated with colonization.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Epidemiology

Background:

  • HIV infection can impact immune function, potentially increasing susceptibility to bacterial infections.
  • Pneumococcus (Streptococcus pneumoniae) is a common cause of bacterial illness in children.
  • Understanding colonization patterns is crucial for public health strategies.

Purpose of the Study:

  • To determine the prevalence of pneumococcus colonization in HIV-infected children (0-18 years).
  • To assess penicillin resistance and identify pneumococcal serotypes.
  • To investigate associations between risk factors and colonization.

Main Methods:

  • Observational, cross-sectional study of 112 HIV-infected children.
  • Nasopharyngeal swabs analyzed for pneumococcus.
  • Questionnaires gathered data on risk factors; serotyping performed by CDC.

Main Results:

  • Prevalence of pneumococcus colonization was 28.6%.
  • Penicillin resistance was 15.6% (6.2% intermediate, 9.4% full resistance).
  • No significant associations found between colonization and studied risk factors.

Conclusions:

  • Pneumococcus colonization prevalence in HIV-infected children was comparable to healthy populations.
  • Serotype distribution and penicillin resistance patterns were characterized.
  • Further research may be needed to understand specific risk factors in this population.
Abstract

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