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Predicting serum gastrin levels among men during Ramadan fasting
M Z A Nomani1, A H Khan, M M Shahda
1Human Nutrition and Foods Program, West Virginia University, Morgantown, West Virginia, USA. mnmani@wvu.edu
Summary
Fasting during Ramadan can increase gastric acidity. This study developed a predictive equation for serum gastrin levels using common clinical lab parameters to help manage acidity.
Area of Science:
- Gastroenterology
- Metabolic Research
Background:
- Increased gastric acidity is a common issue during Ramadan fasting.
- Gastrin, a key hormone in gastric acid secretion, fluctuates during fasting periods.
Purpose of the Study:
- To develop a regression equation for predicting fasting serum gastrin levels.
- To utilize routine clinical laboratory parameters for this prediction.
Main Methods:
- Fasting blood samples were collected from six men on multiple days during Ramadan.
- Serum gastrin, total cholesterol, urea, and uric acid levels were analyzed.
- Multiple regression analysis was employed to establish the prediction equation.
Main Results:
- A statistically significant regression equation was derived: serum gastrin = 198.27 - 0.199(total cholesterol) + 2.525(urea) - 103.238(uric acid) + 10.923(uric acid)^2 + 3.683(body mass index).
- The equation explained 75% of the variance in serum gastrin levels (r^2 = 0.75, P < 0.001).
Conclusions:
- The developed equation can estimate fasting serum gastrin levels.
- This tool may aid in planning dietary and medical interventions to mitigate gastric acidity during Ramadan.