Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Development of antisense nucleotides for therapy].

Ju Wang1, Lei Wang, Youde Wang

  • 1Department of General Surgery, The First Hospital of Jilin University, Changchun 130021, China. wangju_86@163.com

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|March 15, 2006
PubMed
Summary

Antisense oligonucleotides (ASODN) are a genetic therapy that inhibits gene expression by forming double strands with mRNA. This technology offers new treatments for viral infections, tumors, and cardiovascular diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A biomimetic liquid metal cell.

Nanoscale·2026
Same author

The impact of genotype-phenotype on the prognosis of children with hypertrophic cardiomyopathy.

JTCVS open·2026
Same author

Ca2+ sensor CBL2/3-CIPK3/9/26 phosphorylates MTP11 to modulate manganese efflux via degradation and Golgi retention.

Plant physiology·2026
Same author

Pan-neurodegeneration proteomics reveals disease subtypes and molecular signatures.

Cell·2026
Same author

Associations between metal mixture exposure and emotional distress symptoms among pregnant women: A prospective study.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)·2026
Same author

Sox10 glial-neuron nuclear communication mediates anti-apoptosis neuroprotection after ischaemic stroke.

Stroke and vascular neurology·2026

Area of Science:

  • Biotechnology
  • Genetic Pharmacology
  • Molecular Biology

Context:

  • Antisense oligonucleotides (ASODN) leverage base-complementary principles for therapeutic applications.
  • This genetic technology involves transferring synthesized DNA or RNA sequences into target cells.
  • The process forms mRNA-DNA or mRNA-RNA double strands to inhibit specific gene expression.

Purpose:

  • To review the classification and mechanics of antisense oligonucleotides.
  • To explore the wide applications of ASODN in treating viral infections, tumors, and cardiovascular diseases.
  • To identify and discuss current challenges and future directions in ASODN therapy.

Summary:

  • ASODN therapy utilizes synthesized DNA/RNA to bind mRNA, preventing target gene expression.

Related Experiment Videos

  • This mechanism forms the basis for novel genetic pharmacology approaches.
  • The review covers ASODN classifications, mechanisms, and therapeutic potential in various diseases.

    • Impact:

    • ASODN therapy represents a significant advancement in genetic medicine.
    • It offers potential new treatment strategies for challenging diseases.
    • The development of ASODN drugs opens a new frontier in pharmacology.