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Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis.
Ayda Tekok-Kilic1, Ralph H B Benedict, Robert Zivadinov
1Department of Neurology, State University of New York, Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA. atkilic@uludag.edu.tr
Expert Review of Neurotherapeutics
|March 15, 2006
Summary
Multiple sclerosis (MS) involves brain inflammation and damage, often leading to cognitive impairment. Magnetic resonance imaging (MRI) measures help understand brain changes and their link to cognitive function in MS patients.
Area of Science:
- Neuroscience
- Radiology
- Clinical Neurology
Background:
- Multiple sclerosis (MS) is a chronic central nervous system (CNS) inflammatory disease.
- MS is characterized by demyelination and neurodegeneration, causing sensory, motor, and cognitive deficits.
- Cognitive impairment affects approximately 50% of MS patients.
Purpose of the Study:
- To review recent literature on the correlation between magnetic resonance imaging (MRI) and neuropsychological function in MS.
- To highlight the role of neuroimaging in understanding MS pathology and its impact on cognition.
Main Methods:
- Review of recent contributions to the literature.
- Analysis of conventional and nonconventional magnetic resonance imaging (MRI) measures.
- Correlation of neuroimaging findings with neuropsychological test results.
Main Results:
- Structural neuroimaging, particularly MRI, provides crucial information on cerebral pathology in MS.
- Various MRI measures correlate with the degree of brain damage and neurodegeneration.
- These imaging measures are associated with cognitive and affective disturbances in MS patients.
Conclusions:
- Neuroimaging plays a vital role in assessing MS pathology.
- MRI findings correlate significantly with neuropsychological deficits in multiple sclerosis.
- Understanding these correlations aids in managing cognitive impairment in MS.