Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone secretagogues.

Maria Luisa Isidro1, Fernando Cordido

  • 1Endocrinology Department, Hospital Juan Canalejo, La Coruña, Spain.

Combinatorial Chemistry & High Throughput Screening
|March 15, 2006
PubMed
Summary

Growth hormone secretagogues (GHSs) stimulate pituitary growth hormone release through a unique pathway. Research focuses on developing potent oral GHSs, but long-term studies are crucial for clinical evaluation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world outcomes and prognostic factors in anaplastic thyroid cancer: evidence from the REGETNE-Thyroid cohort.

The oncologist·2026
Same author

Sex differences in cardiovascular risk factors and cardiovascular disease in patients with hyperprolactinemia: a multicenter cross-sectional study.

Endocrine·2026
Same author

Sex- and Age-Specific Metabolic Outcomes of Prolactin Normalisation in Hyperprolactinaemia.

Clinical endocrinology·2026
Same author

Efficacy and safety of osilodrostat in patients with ectopic Cushing´s syndrome. a real-world study in Spain.

Journal of endocrinological investigation·2025
Same author

Real-World Data on the Efficacy and Safety of Osilodrostat in Patients with Cushing's Disease in Spain.

Journal of clinical medicine·2025
Same author

Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly.

Pituitary·2025

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Growth hormone secretagogues (GHSs) are synthetic compounds that stimulate pituitary growth hormone (GH) release.
  • GHSs act via a pathway distinct from GH-releasing hormone and somatostatin.
  • Initial GHS discovery in 1977 spurred extensive research into oral formulations.

Purpose of the Study:

  • To review the historical development of GHSs.
  • To explore the potential clinical applications of GHSs.
  • To summarize synthesized GHS types and their activities.

Main Methods:

  • Literature review of GHS research.
  • Analysis of GHS synthesis and biological activity.
  • Evaluation of historical and potential clinical data.

Main Results:

  • GHSs amplify pulsatile GH release.
  • Some GHSs exhibit non-GH-specific pituitary hormone release and GH-independent activities.
  • Numerous GHSs have been synthesized since their discovery.

Conclusions:

  • GHSs represent a significant advancement in GH regulation.
  • Further long-term clinical trials are essential to ascertain GHS efficacy and safety.
  • The review provides a comprehensive overview of GHS history, types, and applications.

Related Experiment Videos