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Aberrant expression of CD95 and CD69 molecules among CD56 cells in women with endometriosis
Audrone Eidukaite1, Almantas Siaurys, Vytas Tamosiunas
1Department of Molecular Immunology, Institute of Immunology, Vilnius, Lithuania. elza@takas.lt
Problem:
Activated lymphocytes can be eliminated by Fas/Fas ligand (FasL)-induced cell death. Endometrial cells express FasL. The aim of our study was to determine the expression of CD56+ cells (natural killer and natural killer T cells) Fas antigen CD95 and the early activation molecule CD69 in the peritoneal fluid of women with endometriosis.
Method:
Two-colour flow cytometry was used.
Results:
In the early stages of endometriosis, more CD56+ cells expressed CD69 and CD95 molecules when compared with the control group. However, in case of severe endometriosis the percentage of CD95+CD56+ cells in peritoneal fluid was similar to that of the control group, but the expression of CD69 molecules remained high.
Conclusion:
Because of Fas/FasL mechanisms, in the initial stages of endometriosis the activated peritoneal fluid CD56+ cells can be intensively eliminated, thus providing conditions for the survival of ectopic endometrial cells and the development of the disease.
