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Related Experiment Videos

Benign tremulous parkinsonism.

Keith A Josephs1, Joseph Y Matsumoto, J Eric Ahlskog

  • 1Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, Minn, USA. josephs.keith@mayo.edu

Archives of Neurology
|March 15, 2006
PubMed
Summary
This summary is machine-generated.

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Benign tremulous parkinsonism is a distinct neurological disorder characterized by tremor. This condition shows minimal progression in other parkinsonian symptoms and often has a poor response to levodopa therapy.

Area of Science:

  • Neurology
  • Movement Disorders
  • Neurodegenerative Diseases

Background:

  • Benign tremulous parkinsonism lacks a precise definition and long-term studies.
  • Characterized by tremor, its clinical features and progression remain under-investigated.

Purpose of the Study:

  • To define the clinical features and longitudinal course of benign tremulous parkinsonism.
  • To differentiate this condition from Parkinson disease (PD).

Main Methods:

  • Retrospective analysis of 116 patients with initial PD diagnosis.
  • 16 patients with benign tremulous parkinsonism and at least an 8-year history were selected.
  • Key data included age at onset, levodopa response, tremor type, and family history.

Main Results:

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  • Mean disease duration was 11 years; mean age at onset was 58.5 years.
  • Most patients exhibited poor levodopa response and moderate to marked postural/kinetic tremor.
  • A family history of tremor or PD was reported in 63% of patients; 3 required deep brain stimulation.

Conclusions:

  • Benign tremulous parkinsonism may be a distinct entity with tremor predominance and slow progression.
  • Tremor in this condition is often unresponsive to levodopa.
  • A significant family history of tremor or PD is common in affected individuals.