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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Coronary surgery in patients requiring chronic hemodialysis
T Krabatsch1, R Yeter, R Hetzer
1Deutsches Herzzentrum Berlin, Klinik fur Herz-, Thorax- und Gefasschirurgie, Berlin, Deutschland, Germany. krabatsch@dhzb.de
Insights
Coronary artery bypass grafting (CABG) in chronic dialysis patients has a 5.6% perioperative mortality. Mid-term survival is acceptable when tailored care is provided for this unique patient group.
Area of Science:
- Cardiovascular Surgery
- Nephrology
- Critical Care Medicine
Background:
- Coronary artery bypass grafting (CABG) in patients with chronic kidney disease on hemodialysis presents unique perioperative challenges.
- Uremic patients often have comorbidities, including peripheral artery disease and anemia, complicating surgical management.
Purpose of the Study:
- To evaluate the outcomes of CABG in patients requiring chronic hemodialysis.
- To compare the results with a matched control group of non-uremic patients undergoing CABG.
Main Methods:
- Retrospective analysis of 71 chronic dialysis patients who underwent CABG between 2001 and 2004.
- Comparison with a randomized control group of 68 non-uremic patients who underwent CABG during the same period.
Main Results:
- The incidence of CABG among chronic dialysis patients was 1.12% (71 out of 6315).
- Perioperative mortality in the dialysis group was 5.6%.
- One-year survival was 87.7% for uremic patients vs. 91.0% for controls; 4-year survival was 56.7% vs. 88.0%, respectively. Dialysis patients had higher rates of peripheral artery disease, lower hemoglobin, and required more transfusions.
Conclusions:
- Coronary artery bypass grafting can be performed in uremic patients with acceptable mid-term survival rates.
- Careful consideration of the specific needs of dialysis patients is crucial for successful perioperative management and improved outcomes.
Background:
In uremic patients coronary surgery and the entire perioperative management is demanding.
Methods:
We analyzed retrospectively data from all patients requiring chronic hemodialysis who under went coronary artery bypass grafting (CABG) between January 1 2001 and December 31 2004 at the Deutsches Herzzentrum Berlin and compared them to those of a randomized nonuremic control group (n = 68), which consisted of patients who underwent CABG during the same period.
Results:
During the study period 6315 patients underwent coronary artery bypass grafting at the Deutsches Herzzentrum Berlin. Among these patients, we identified 71 chronic dialysis patients (1.12%). Among dialysis patients, we recorded a perioperative mortality of 5.6%. One-year survival rate was 87.7% among uremic patients and 91.0% in the control group; the corresponding 4-year survival rates were 56.7 and 88.0%, respectively. The incidence of peripheral artery disease was significantly higher in the dialysis group. Uremic patients showed significantly lower hemoglobin serum levels at the time of admission compared to the control group (11.4 +/- 1.62 vs. 13.3 +/- 1.81 mg/dl). These patients received significantly higher numbers of blood transfusions (6.7 +/- 5.6 vs. 2.75 +/- 3.8), and platelet transfusions.
Conclusion:
Our preliminary study indicates that coronary surgery can be performed with acceptable mid-term results when the specific requirements of this patient group are taken into account.
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