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Related Experiment Videos

Anesthetics and brain toxicity.

Sulpicio G Soriano1, Kanwaljeet Js Anand

  • 1Department of Anesthesiology, Children's Hospital, Boston, MA 02115, USA. Sulpico.Soriano@childrens.harvard.edu

Current Opinion in Anaesthesiology
|March 15, 2006
PubMed
Summary
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Anesthetic drugs may cause neurodegeneration in developing brains, but rodent study findings are not directly applicable to human neonates. Further research is needed before altering pediatric anesthesia protocols.

Area of Science:

  • Neuroscience
  • Anesthesiology
  • Developmental Biology

Background:

  • Rodent studies suggest anesthetic drugs may induce neurodegeneration in developing brains.
  • Concerns exist regarding the safety of anesthetic use in pediatric anesthesia.

Purpose of the Study:

  • To review scientific evidence on anesthetic-induced neurotoxicity.
  • To assess the applicability of these findings to human neonates.

Main Methods:

  • Review of experimental data from rodent studies on anesthetic exposure.
  • Analysis of neurodegeneration and behavioral changes in young rodents.

Main Results:

  • Prolonged exposure to anesthetics (ketamine, isoflurane, nitrous oxide, midazolam) caused neurodegeneration in rat pups.

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  • Combined anesthetic use altered adult learning behavior in rodents.
  • Rodent findings could not be reproduced in other species; withholding anesthesia caused adverse responses.

    • Conclusions:

    • Rodent study results raise questions about their applicability to human neonates.
    • Further investigation is required before withholding anesthesia in pediatric patients.