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Thrombogenic risk factors for atherothrombosis

Prediman K Shah1

  • 1Atherosclerosis Research Center, Division of Cardiology and Department of Medicine, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Reviews in Cardiovascular Medicine
|March 15, 2006
PubMed

Insights

Most acute ischemic events stem from thrombosis on disrupted plaques. Researchers are investigating novel hemostatic risk factors beyond traditional atherosclerosis markers to understand these events better.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Genetics

Background:

  • Acute ischemic syndromes and sudden cardiac death are often triggered by thrombosis on disrupted atherosclerotic plaques.
  • A notable proportion of these events occur in individuals lacking conventional atherosclerosis risk factors, suggesting other contributing elements.
  • Understanding these additional factors is crucial for comprehensive risk assessment and prevention strategies.

Purpose of the Study:

  • To identify and discuss potential hemostatic risk factors contributing to acute ischemic events.
  • To explore the evidence linking these factors to atherothrombotic events, particularly in individuals without traditional risk factors.
  • To examine the role of the thrombotic cascade, cellular components, plasma proteins, and genetic polymorphisms in atherothrombosis.

Main Methods:

  • Review and synthesis of existing research on hemostatic factors and atherothrombotic events.
  • Examination of the thrombotic cascade and its cellular and molecular components.
  • Analysis of genetic polymorphisms associated with hemostatic pathways.
  • Discussion of evidence linking specific hemostatic risk factors to clinical outcomes.

Main Results:

  • Thrombosis on disrupted plaques is a primary cause of acute ischemic events.
  • Several hemostatic factors, including genetic variations, are implicated as potential risk factors.
  • Evidence links these factors to atherothrombotic events, even in the absence of traditional risk factors.
  • The thrombotic system's components and their genetic makeup play a significant role.

Conclusions:

  • Hemostatic factors represent important, often overlooked, risk factors for acute ischemic events.
  • Further research into these factors can improve the identification and management of individuals at risk.
  • Genetic polymorphisms within the hemostatic system may offer novel insights into atherothrombotic disease susceptibility.

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