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Palliative radiation therapy for metastatic Ewing sarcoma.

Bridget F Koontz1, Robert W Clough, Edward C Halperin

  • 1Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA. koont005@radonc.duke.edu

Cancer
|March 15, 2006
PubMed
Summary

Palliative radiotherapy effectively managed symptoms in patients with metastatic Ewing sarcoma (EWS), with over half experiencing complete or partial symptom relief. This approach offers valuable symptom control for patients with a median survival of one year post-metastasis diagnosis.

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Area of Science:

  • Oncology
  • Palliative Care
  • Radiation Oncology

Background:

  • Ewing sarcoma (EWS) treatment often includes radiotherapy for curative intent.
  • Data on palliative radiotherapy for metastatic EWS is limited.
  • This study reviews the Duke University Medical Center experience with palliative radiotherapy for EWS.

Purpose of the Study:

  • To evaluate the effectiveness and durability of palliative radiotherapy in patients with metastatic Ewing sarcoma.
  • To assess treatment response and symptom relief in EWS patients receiving palliative radiation.

Main Methods:

  • Retrospective review of 21 patients with metastatic EWS treated with palliative radiotherapy between 1980 and 2002.
  • Pain was the primary indication for treatment.
  • Sixty-three metastatic sites were irradiated with a median dose of 30 Gy.

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Main Results:

  • 55% of irradiated sites showed a complete clinical response, and 29% showed a partial response.
  • The median duration of symptom response was 4.0 months.
  • One patient with brain metastasis achieved long-term disease-free survival; others died of disease, with a median survival of 1.0 year post-metastasis diagnosis.

Conclusions:

  • Palliative radiotherapy is an effective treatment for metastatic Ewing sarcoma.
  • Symptom relief is a valuable and appropriate goal for patients with metastatic EWS, given the median survival of one year.
  • The treatment course should be manageable, focusing on symptom control without excessive burden.