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Multiple simian virus 40 enhancer elements mediate the trans-activating function of the X protein of hepatitis B
B Luber1, E Bürgelt, C Fromental
1Max-Planck-Institut für Biochemie, Martinsried, FRG.
Virology
|October 1, 1991
Abstract:
Transient transfections of tissue culture cells with plasmids encoding the X protein of hepatitis B virus result in a transcriptional trans-activation of certain target genes. Our experiments reveal that several individual simian virus 40 enhancer elements and a control element present in the mouse major histocompatibility class I gene H-2Kb are able to mediate the trans-activating function of the X protein. The data suggest that known cellular transcription factors that bind specifically to the multiple enhancer elements participate in trans-activation.