Related Experiment Video
Updated: Aug 10, 2026

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
Bactericidal mode of action of plantaricin C
Abstract:
Plantaricin C is a bacteriocin produced by Lactobacillus plantarum LL441 that kills sensitive cells by acting on the cytoplasmic membrane. In contrast to its lack of impact on immune cells, plantaricin C dissipates the proton motive force and inhibits amino acid transport in sensitive cells. In proteoliposomes, plantaricin C dissipates the transmembrane electrical potential, and in liposomes, it elicits efflux of entrapped carboxy-fluorescein. It is concluded that plantaricin C is a pore-forming bacteriocin that functions in a voltage-independent manner and does not require a specific protein receptor in the target membrane.
Related Concept Videos
Inhibitors of Gram-positive Cell Wall Synthesis
Biological Methods for Microbial Control
Clinical Significance of Antibiotic Resistance
Chemical Agents for Microbial Control
Methods for Controlling Microbial Growth
Antifungal Agents
