Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Open angle glaucoma: epidemiology, pathogenesis and prevention].

Alberto Izzotti1, Barbara Di Marco, Silvio De Flora

  • 1Dipartimento di Scienze della Salute, Università, Genova.

Recenti Progressi in Medicina
|March 16, 2006
PubMed
Summary

Reactive oxygen species (ROS) contribute to primary open angle glaucoma (POAG) pathogenesis. Oxidative DNA damage in the trabecular meshwork and genetic factors in POAG patients highlight ROS

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MicroRNA and Cancer: A History of Medical Successes and Opportunities.

MicroRNA (Shariqah, United Arab Emirates)·2026
Same author

Safety and efficacy of hormonal therapies used to treat endometriosis in women suffering migraine.

Expert opinion on drug safety·2026
Same author

Experimental Evaluation of the Efficacy of Air-Sanitizing Equipment in Neutralizing Airborne SARS-CoV-2 Virus.

Pathogens (Basel, Switzerland)·2025
Same author

Microrna Expression in <i>Aurelia aurita</i> Metamorphosis.

MicroRNA (Shariqah, United Arab Emirates)·2025
Same author

Antioxidant Food Supplementation in Cancer: Lessons from Clinical Trials and Insights from Preclinical Studies.

Antioxidants (Basel, Switzerland)·2025
Same author

Recent Advances in Amyloids Structural Studies and Thin Film Applications.

Molecules (Basel, Switzerland)·2025

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Primary open angle glaucoma (POAG) pathogenesis is increasingly linked to reactive oxygen species (ROS).
  • Oxidative DNA damage, specifically 8-hydroxy-2'-deoxyguanosine, is elevated in the trabecular meshwork (TM) of glaucoma patients.
  • Evidence suggests ROS contribute to increased outflow resistance and compromise TM integrity.

Purpose of the Study:

  • To explore the role of ROS in POAG pathogenesis.
  • To investigate the correlation between oxidative DNA damage and intraocular pressure in POAG.
  • To examine genetic predispositions related to antioxidant activity in POAG.

Main Methods:

  • Measurement of 8-hydroxy-2'-deoxyguanosine in TM tissue.
  • Analysis of antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase) in aqueous humor.

Related Experiment Videos

  • Genetic analysis for glutathione-S-transferase M1 (GSTM1) gene deletions.

    • Main Results:

    • Elevated oxidative DNA damage and increased antioxidant enzyme activity in POAG patients.
    • Correlation found between oxidative DNA damage and intraocular pressure.
    • Increased frequency of GSTM1 gene deletion in POAG patients, suggesting genetic susceptibility.

    Conclusions:

    • ROS play a significant role in POAG pathogenesis, affecting both TM and retinal cells.
    • Genetic predisposition and oxidative stress are key factors in POAG development.
    • Future strategies may involve genetic screening and ROS-attenuating therapies for POAG prevention.