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Related Experiment Videos

Lisinopril versus atenolol: decrease in systolic versus diastolic blood pressure with converting enzyme inhibition.

B E Pannier1, V G Garabedian, O Madonna

  • 1Department of Internal Medicine, Broussais Hospital, Paris, France.

Cardiovascular Drugs and Therapy
|August 1, 1991
PubMed
Summary

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Lisinopril and atenolol effectively lowered blood pressure in patients with essential hypertension. Lisinopril demonstrated a superior reduction in systolic blood pressure compared to atenolol.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Essential hypertension is a prevalent cardiovascular condition requiring effective management.
  • Converting enzyme inhibitors represent a class of antihypertensive medications.

Purpose of the Study:

  • To compare the efficacy of lisinopril, a novel converting enzyme inhibitor, with atenolol in treating mild to moderate essential hypertension.
  • To evaluate the impact of both drugs on sitting diastolic and systolic blood pressure.

Main Methods:

  • A multicenter, parallel, double-blind study involving 490 patients.
  • Randomized once-a-day treatment with lisinopril (20-80 mg) or atenolol (50-200 mg) for 8 weeks.
  • Dose escalation based on sitting diastolic blood pressure control.

Main Results:

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  • Both lisinopril and atenolol significantly reduced sitting diastolic blood pressure (SDBP).
  • Lisinopril achieved a significantly greater reduction in sitting systolic blood pressure (SSBP) compared to atenolol.
  • Reductions in both SDBP and SSBP from baseline were statistically significant (p < 0.01).

Conclusions:

  • Lisinopril and atenolol are effective in managing essential hypertension.
  • Lisinopril offers a potential advantage in reducing systolic blood pressure, possibly due to increased arterial compliance.
  • Further research may explore the mechanisms behind lisinopril's predominant systolic blood pressure reduction.