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[Stress and microgravity].

S I Stepanova

    Aviakosmicheskaia I Ekologicheskaia Meditsina = Aerospace and Environmental Medicine
    |March 16, 2006
    PubMed
    Summary
    This summary is machine-generated.

    Microgravity may not be stressful because it suppresses typical stress responses. This suppression might prevent muscle atrophy by blocking adrenal functions, but microgravity remains a stressor.

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    Area of Science:

    • Space biology
    • Human physiology
    • Stress research

    Context:

    • The physiological effects of microgravity are not fully understood.
    • A common viewpoint suggests microgravity is not a stressor due to a lack of adrenal activation evidence.
    • Mammalian and human responses to spaceflight require further investigation.

    Purpose:

    • To present an argument for the stressful nature of microgravity.
    • To propose a mechanism by which microgravity acts as a stressor.
    • To reconcile the apparent lack of stress response with microgravity's known effects.

    Summary:

    • Microgravity may suppress hypothalamo-pituitary-adrenal and sympathoadrenal systems.
    • This suppression could be a mechanism to prevent muscle atrophy by blocking stress-related catabolic pathways.

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  • The organism might inhibit glucocorticoid and catecholamine functions of the adrenals to counteract microgravity's effects.

    • Impact:

    • Microgravity significantly alters the stress response pattern.
    • This perspective does not negate microgravity's role as a stress factor.
    • Understanding these modified stress pathways is crucial for astronaut health and long-duration space missions.