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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Allergic contact dermatitis from propolis
Susan E Walgrave1, Erin M Warshaw, Lynn A Glesne
1University of Minnesota, School of Medicine, Minneapolis, MN, USA.
Abstract:
Propolis is commonly used in cosmetic and medicinal preparations because of its antiseptic, antiinflammatory, and anesthetic properties. Its therapeutic qualities have been well documented. However, 1.2 to 6.6% of patients who are patch-tested for dermatitis are sensitive to propolis. The main allergens are 3-methyl-2-butenyl caffeate and phenylethyl caffeate. Benzyl salicylate and benzyl cinnamate are less frequent sensitizers. Propolis is found in a number of "natural" products, including lip balms, cosmetics, lotions and ointments, shampoos, conditioners, and toothpastes. Dermatologists should consider patch testing with propolis in users of such remedies.
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