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Endoglin (CD105) expression in human renal cell carcinoma
Johanna Sandlund1, Ylva Hedberg, Anders Bergh
1Department of Radiation Sciences, Oncology, Umeå University, SE-901 85 Umeå, Sweden.
BJU International
|March 16, 2006
Summary
Endoglin (CD105) expression in renal cell carcinoma (RCC) inversely correlates with tumor stage and grade. While associated with prognosis, it did not independently predict outcomes in this study.
Area of Science:
- Oncology
- Pathology
- Biomarker Research
Background:
- Endoglin (CD105) is a cell membrane glycoprotein and a marker of angiogenesis.
- Intratumoral microvessel density, assessed by endoglin staining, has prognostic significance in some cancers.
Purpose of the Study:
- To evaluate the prognostic potential of endoglin (CD105) expression in human renal cell carcinoma (RCC).
Main Methods:
- Tissue microarray technique with immunohistochemical staining for endoglin.
- Assessment of endoglin expression in 210 RCC patient tumor samples.
- Correlation of endoglin expression with clinical variables and patient survival.
Main Results:
- 75% of RCC tumors expressed endoglin.
- Endoglin expression inversely correlated with Tumor-Node-Metastasis (TNM) stage and nuclear grade in conventional RCC.
- Patients with high endoglin expression in conventional RCC had a more favorable prognosis (P = 0.04).
- TNM stage and nuclear grade were independent predictors of prognosis; endoglin expression did not add further prognostic information.
Conclusions:
- Endoglin expression is inversely related to stage and grade in renal cell carcinoma.
- Endoglin expression is associated with prognosis in RCC, but not an independent predictor.
