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[Increasing methylase-mediated resistance to macrolides in Streptococcus pyogenes in a children's hospital in

Amadeu Gené1, Carmen Ardanuy, Edgar Palacín

  • 1Servicio de Microbiología, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain. agene@hsjdbcn.org

Enfermedades Infecciosas Y Microbiologia Clinica
|March 16, 2006
PubMed
Abstract

Insights

Streptococcus pyogenes resistance to clarithromycin and clindamycin increased significantly, driven by genetic changes like MLSB phenotype. This rise in resistance compromises the effectiveness of these crucial antibiotics.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Infectious Diseases

Context:

  • Study conducted on 480 Streptococcus pyogenes strains from a Barcelona children's hospital (1996-2003).
  • Focus on resistance mechanisms to clarithromycin and clindamycin.

Purpose:

  • Investigate the genetic mechanisms and evolving resistance patterns of Streptococcus pyogenes to macrolides and clindamycin.
  • Analyze trends in antibiotic resistance over an eight-year period.

Summary:

  • Observed a progressive increase in strains exhibiting the Macrolide-Lincosamide-Streptogramin B (MLSB) resistance phenotype, reaching 55.6% in 2002.
  • Overall macrolide resistance rose from 27.4% (1996-2001) to 35.8% (2002-2003).
  • Identified specific genes: mefA (M phenotype), ermB (constitutive MLSB), and ermTR (inducible MLSB).

Impact:

  • The increasing resistance and changing genetic mechanisms diminish the therapeutic efficacy of macrolides and clindamycin.
  • Highlights the need for ongoing surveillance of antibiotic resistance in Streptococcus pyogenes.

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