Related Experiment Video
Updated: Aug 10, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Child care and social support modify the association between maternal depressive symptoms and early childhood
Li-Ching Lee1, Carolyn T Halpern, Irva Hertz-Picciotto
1Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Room E6032, Baltimore, MD 21205, USA. llee2@jhsph.edu
Objective:
To investigate the presence and patterns of modification effects of the sex of the child, social support, and childcare on the relation between maternal depressive symptoms and child behaviour problems at two developmental stages.
Design:
Analyses are based on prospective longitudinal data from the study of early child care.
Participants:
A total of 1216 families were drawn from 10 locations across the USA. Mothers were age 18 or older at the time of the study child's birth and had completed outcome measures for at least one follow up time point (24 months, 36 months).
Main Outcome Measures:
Child internalising and externalising behaviour problems assessed at the child's age of 24 months and 36 months, as reported by the mother.
Results:
Results from generalised estimating equation analyses showed that the association between child externalising behaviour problems and maternal depressive symptoms varied according to the social support received by the mother (p<0.05). Overall, social support mitigated the relation, but protective effects diminished at increasing levels of depressive symptoms. Associations between child internalising behaviour problems and maternal depressive symptoms varied according to whether or not the child received care from caregivers other than the mother (p<0.05).
Conclusions:
Health providers who are working with mothers with depressive symptoms may want to examine social support that is available to mothers, especially if mothers are not severely depressed. Furthermore, recommendations to begin, continue, or perhaps increase provision of childcare from other caregivers can provide respite for mothers and opportunities for children to engage in protective interactions with others.
Related Concept Videos
Socioemotional Development during Infancy
Primary Temperament Types
Stella Chess...
Relationship with Parents: Attachment
Psychological and Sociocultural Causes of Schizophrenia
Attachment
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Parenting Styles
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative Parenting
This...

