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Related Experiment Videos

Mortality and vascular outcomes in patients treated for thyroid dysfunction.

R W V Flynn1, T M Macdonald, R T Jung

  • 1Wards 1 and 2, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom.

The Journal of Clinical Endocrinology and Metabolism
|March 16, 2006
PubMed
Summary

This study found no increased mortality in treated thyroid disease patients. However, treated hypothyroidism patients had higher risks of ischemic heart disease and dysrhythmias, while hyperthyroidism patients showed increased dysrhythmia risk.

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Public Health

Background:

  • Limited data exist on mortality and morbidity in treated hyperthyroidism patients.
  • No prior data available on mortality and morbidity in treated hypothyroidism patients.

Purpose of the Study:

  • To describe all-cause mortality and vascular mortality and morbidity in patients treated for hyperthyroidism and hypothyroidism.

Main Methods:

  • Population-based cohort study (1994-2001) in Tayside, Scotland.
  • Compared event rates in thyroid dysfunction patients to the general population using standardized mortality and incidence ratios.
  • Primary outcome: all-cause mortality. Secondary outcome: serious vascular events (myocardial infarction, stroke, vascular death).

Main Results:

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  • No increase in all-cause mortality or serious vascular events for treated hypothyroidism or hyperthyroidism.
  • Increased risk of nonfatal ischemic heart disease (SIR 1.23) and dysrhythmias (SIR 1.32) in treated hypothyroidism.
  • Increased risk of dysrhythmias (SIR 2.71) in treated hyperthyroidism; no increased risk of heart failure or cerebrovascular disease in either group.

Conclusions:

  • Treated thyroid disease does not increase all-cause mortality.
  • Increased cardiovascular morbidity risk observed in treated hypothyroidism (ischemic heart disease, dysrhythmias) and treated hyperthyroidism (dysrhythmias).