Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selenium, apoptosis, and colorectal adenomas.

Alexandra Connelly-Frost1, Charles Poole, Jessie A Satia

  • 1R. Stuart Dickson Institute for Health Studies, 720 East Morehead Street, Charlotte, NC 28232, USA. aconnell@email.unc.edu

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|March 16, 2006
PubMed
Summary

Higher selenium intake was linked to fewer colorectal adenomas, a precursor to cancer. However, the study found that apoptosis, a cell death process, did not appear to be the mechanism behind this association.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of Variation in Botanical Supplement Use among Hispanics and Latinos in the United States.

Epidemiology (Sunnyvale, Calif.)·2026
Same author

Influence of Gestational Age Measurement Technique on the Associations Between Maternal Characteristics and Birth Outcomes.

Paediatric and perinatal epidemiology·2026
Same author

Pregnancy Length Measurement Error: A Comparison of Last Menstrual Period and Ultrasonography with Ovulation-based Estimation.

Epidemiology (Cambridge, Mass.)·2025
Same author

The exposure potential restriction rule revisited.

American journal of epidemiology·2025
Same author

[Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration - a Korean translation].

Ewha medical journal·2025
Same author

Evaluating behavioral goals for eating timing, frequency, and distribution of daily carbohydrate consumption among youth with type 1 diabetes (MyPlan): A single arm pilot and feasibility study.

Diabetes research and clinical practice·2025

Area of Science:

  • Nutritional biochemistry
  • Gastroenterology
  • Cancer prevention research

Background:

  • Selenium is an essential trace element crucial for various bodily functions.
  • It is found in common foods like cereals, meat, and fish.
  • Selenium may play a role in preventing cancer through pathways like apoptosis.

Purpose of the Study:

  • To investigate the association between selenium levels and colorectal adenoma prevalence.
  • To explore the relationship between selenium and apoptosis, a key cellular process.
  • To understand selenium's potential role in colorectal cancer prevention.

Main Methods:

  • Cross-sectional study (Diet and Health Study III) with 803 participants.
  • Serum selenium levels measured during colonoscopy.

Related Experiment Videos

  • Apoptosis assessed in rectal tissue biopsies.

    • Main Results:

    • Individuals with higher serum selenium showed a reduced prevalence of colorectal adenomas.
    • A trend suggested an inverse association between selenium and apoptosis, but it was not strongly significant.
    • Apoptosis did not appear to be the primary mechanism linking selenium to adenoma prevalence.

    Conclusions:

    • Elevated selenium levels are associated with a lower prevalence of colorectal adenomas.
    • The mechanism of selenium's effect on adenoma prevalence does not seem to involve apoptosis based on this study's findings.
    • Further research may be needed to elucidate the precise mechanisms of selenium's chemopreventive effects.