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Transition from meeting abstract to full-length journal article for randomized controlled trials
Mustafa Toma1, Finlay A McAlister, Liza Bialy
1The Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, Canada.
JAMA
|March 16, 2006
Summary
Late-breaking randomized controlled trials (RCTs) presented at scientific meetings are larger, published faster, and less likely to report favorable results. However, discrepancies between abstract and full publication findings are common for all RCTs.
Area of Science:
- Cardiology
- Clinical Trials
- Scientific Publishing
Background:
- Scientific meeting presentations may differ from published research.
- Publication fate and consistency of randomized controlled trials (RCTs) from late-breaking sessions are not well-studied.
- Understanding publication patterns is crucial for accurate scientific interpretation.
Purpose of the Study:
- To compare randomized controlled trials (RCTs) presented in late-breaking sessions versus other sessions at a major scientific meeting.
- To assess the publication fate and consistency of results between abstracts and full-length articles for these RCTs.
Main Methods:
- Hand-searched abstract proceedings and websites for American College of Cardiology scientific meetings (1999-2002) to identify RCTs.
- Utilized electronic databases to identify subsequent full-length publications.
- Compared publication rates, time to publication, and consistency of efficacy estimates between abstracts and articles.
Main Results:
- Late-breaking RCTs were larger, more likely to have a published design paper, and of higher quality upon publication.
- RCTs in late-breaking sessions were published more frequently and sooner than those in other sessions.
- Discrepancies between abstract and publication efficacy estimates occurred in 41% of published RCTs, with similar rates for late-breaking and other sessions.
Conclusions:
- Late-breaking trials exhibit distinct characteristics, including larger size and earlier publication, but not necessarily greater accuracy.
- Discrepancies between presented and published results are a common issue, even for late-breaking trials.
- Careful comparison of abstract and full publication data is necessary for all randomized controlled trials.
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