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Related Experiment Videos

Drug-induced thyrotoxic periodic paralysis.

Michael P Kane1, Robert S Busch

  • 1Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208, USA. kanem@acp.edu

The Annals of Pharmacotherapy
|March 16, 2006
PubMed
Summary

A rare case of thyrotoxic periodic paralysis (TPP) was triggered by iodine-induced hyperthyroidism (Jod-Basedow) after cardiac catheterization. Prompt diagnosis and treatment of TPP are crucial for managing this potentially life-threatening condition.

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Area of Science:

  • Endocrinology
  • Cardiology
  • Neurology

Background:

  • Iodine contrast dyes can induce hyperthyroidism, a condition known as Jod-Basedow.
  • Thyrotoxic periodic paralysis (TPP) is a rare complication of hyperthyroidism, particularly in Caucasian males.
  • Cardiac catheterization with iodinated contrast is a potential trigger for Jod-Basedow hyperthyroidism.

Observation:

  • A 64-year-old male presented with profound extremity weakness and hypokalemia post-cardiac catheterization.
  • The patient's symptoms resolved with potassium supplementation.
  • He was subsequently diagnosed with Jod-Basedow hyperthyroidism, likely induced by the iodinated contrast dye.

Findings:

  • The patient developed thyrotoxic periodic paralysis (TPP) following iodine exposure from cardiac catheterization.

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  • This represents a rare instance of iodine-induced TPP in a Caucasian patient.
  • The Naranjo scale confirmed a probable link between the contrast dye and the TPP episode.

    • Implications:

    • Clinicians must consider drug-induced thyroid disease and its complications, such as TPP.
    • TPP should be suspected in patients with acute weakness and hypokalemia, especially after procedures involving iodine contrast.
    • Early diagnosis and management of TPP are vital to prevent severe outcomes.