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Updated: Aug 10, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Glucose-insulin and potassium infusions in septic shock
Shahir S Hamdulay1, Ali Al-Khafaji, Hugh Montgomery
1Department of Intensive Care Medicine, University College London Foundation Hospitals, The Middlesex Hospital, London W12 0HS, UK. sh_hamdu@hotmail.com
Abstract:
Glucose-insulin and potassium (GIK) infusions are beneficial in treating ischemic myocardial depression. Myocardial depression is also an important feature in septic shock. We describe two cases of pressor-resistant hypodynamic septic shock that responded to high-dose GIK infusions. In each case, hemodynamic profiles improved sufficiently to allow withdrawal of vasopressor agents. Further assessment of GIK in patients with hypodynamic septic shock is necessary to confirm efficacy and prognostic significance.
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