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Updated: Aug 10, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
Catastrophic antiphospholipid syndrome related to severe ovarian hyperstimulation
V Giner1, M R Oltra, M J Esteban
1Department of Internal Medicine, Hospital Clínico Universitario, University of Valencia, 46010, Valencia, Spain. giner_vicgal@gva.es
Abstract:
Antiphospholipid syndrome (APS) is a cause of infertility and fetal loss. Ovarian stimulation can induce previously unknown APS. Ovarian hyperstimulation syndrome (OHS) is uncommon but potentially life-threatening, as well as catastrophic APS. A woman that simultaneously developed a severe OHS and a catastrophic APS is described in this paper. Both entities produced thrombotic cardiac and brain thrombosis. A peculiar mechanism of cardiac ischemia is also described. In spite of the life-threatening risk of this situation, the indication for preventive anti-aggregation and/or anticoagulation is not clear.
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