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Related Experiment Videos

Assessing cognitive function in cancer patients.

Janette Vardy1, Karen Wong, Qi-Long Yi

  • 1Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada. janette.vardy@uhn.on.ca

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
|March 16, 2006
PubMed
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Cognitive impairment after chemotherapy is common. CogHealth and Headminder are suitable for non-English speakers, but the High Sensitivity Cognitive Screen (HSCS) shows practice effects.

Area of Science:

  • Oncology
  • Neuroscience
  • Psychometrics

Background:

  • Chemotherapy can cause cognitive impairment in cancer patients.
  • There is a need for brief, sensitive screening tools for chemotherapy-induced cognitive impairment.
  • Evaluating cognitive function post-treatment is crucial for patient well-being.

Purpose of the Study:

  • To compare the effectiveness of three cognitive screening instruments in cancer patients.
  • To assess the suitability of screening tools for diverse patient populations, including non-English speakers.
  • To identify reliable methods for detecting cognitive deficits after chemotherapy.

Main Methods:

  • 31 cancer patients receiving adjuvant chemotherapy within two years were evaluated.
  • Cognitive function was assessed using High Sensitivity Cognitive Screen (HSCS), Headminder, CogHealth, and FACT-COG.

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  • Patients fluent and not fluent in English were included to test instrument applicability.

    • Main Results:

    • Baseline cognitive impairment was detected by HSCS (30%), Headminder (55%), and CogHealth (26%).
    • A significant practice effect was observed for HSCS, reducing its reliability for repeated measures.
    • FACT-COG showed patient-reported cognitive decline (47%) and quality of life impact (53%), but poorly correlated with objective tests.

    Conclusions:

    • CogHealth and Headminder are appropriate for non-English speaking cancer patients.
    • HSCS is not recommended for longitudinal studies due to practice effects.
    • Patient perception of cognitive impairment does not strongly correlate with objective cognitive test results.