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Related Experiment Videos

Does seasonal variation affect hallucinations in PD? A longitudinal study.

Christopher G Goetz1, John Michael Li, Joanne Wuu

  • 1Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA. cgoetz@rush.edu

Movement Disorders : Official Journal of the Movement Disorder Society
|March 16, 2006
PubMed
Summary

Visual hallucinations in Parkinson's disease (PD) patients do not worsen in winter. This study found no seasonal variation in hallucination severity, suggesting chronobiology interventions are not a priority for PD hallucinations.

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Movement Disorders

Background:

  • Visual hallucinations are a common and distressing non-motor symptom in Parkinson's disease (PD).
  • The potential influence of seasonal changes and chronobiology on hallucination severity in PD remains largely unexplored.

Purpose of the Study:

  • To investigate the chronobiology of visual hallucinations in Parkinson's disease (PD) patients.
  • To determine if hallucination severity in PD patients is exacerbated during winter months compared to summer months.

Main Methods:

  • Longitudinal data on the Unified Parkinson's Disease Rating Scale (UPDRS) Thought Disorder (TD) score were analyzed in hallucinating PD patients over a 1-year cycle.
  • Analysis focused on patients with stable medication regimens to minimize confounding factors.

Related Experiment Videos

  • Wilcoxon rank-sum tests compared hallucination severity (TD score or neuroleptic use) between winter and summer seasons.

    • Main Results:

    • No significant difference was found in hallucination severity between winter and summer months (P = 0.42).
    • Wintertime exacerbation of hallucinations was not greater than summertime exacerbation in PD patients on stable medications.

    Conclusions:

    • The darkness of winter does not appear to exacerbate visual hallucinations in Parkinson's disease patients with stable medication.
    • Current findings do not support phototherapy or other chronobiological interventions as research priorities for treating PD-associated hallucinations.