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Related Experiment Videos

Expression of Prox1 during mouse cochlear development.

Olivia Bermingham-McDonogh1, Elizabeth C Oesterle, Jennifer S Stone

  • 1Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology, University of Washington School of Medicine, Seattle, Washington 98195, USA. oliviab@u.washington.edu

The Journal of Comparative Neurology
|March 16, 2006
PubMed
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Prox1, a key transcription factor, is expressed in developing mouse inner ear sensory cells. Its dynamic expression pattern in hair and support cells provides a foundation for understanding sensory development.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • Prox1 is a homeo-domain transcription factor crucial for development.
  • Understanding gene expression during inner ear development is vital for auditory system research.

Purpose of the Study:

  • To analyze the expression pattern of Prox1 during mouse inner ear development.
  • To establish a baseline for future studies on Prox1's role in sensory development.

Main Methods:

  • Analysis of Prox1 expression using immunohistochemistry.
  • Double labeling with cell-type-specific markers in mouse embryos and postnatal mice.

Main Results:

  • Prox1 expression begins in the otocyst at embryonic day 11, initially in vestibular sensory patches.

Related Experiment Videos

  • In the auditory system, Prox1 is expressed in the cochlear sensory epithelium from embryonic day 14.5, becoming restricted to specific support cells (Deiters' and pillar cells) postnatally.
  • Outer hair cells transiently express Prox1, while support cells maintain expression into the second postnatal week.

    • Conclusions:

    • Prox1 exhibits dynamic expression during inner ear development, particularly in the auditory system.
    • The identified expression patterns in hair and support cells are critical for understanding Prox1's function in sensory development.