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Mycoplasma pneumonia with antiphospholipid antibodies and a cardiac thrombus

M Bakshi1, C Khemani, V Vishwanathan

  • 1Pediatric Rheumatology Clinic, Jaslok Hospital and Research Center, Mumbai, India.

Lupus
|March 17, 2006
PubMed

Insights

A four-year-old child developed a left atrial thrombus due to antiphospholipid (aPL) antibodies during Mycoplasma pneumoniae infection. Anticoagulation therapy led to complete thrombus resolution within six months.

Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Rheumatology

Background:

  • Mycoplasma pneumoniae infections can trigger autoimmune responses.
  • Antiphospholipid antibodies (aPL) are associated with thrombotic events.
  • Cardiac thrombi are rare but serious complications in pediatric infections.

Observation:

  • A four-year-old child presented with Mycoplasma pneumoniae pneumonia.
  • Echocardiography revealed a significant left atrial thrombus.
  • Laboratory tests confirmed the presence of antiphospholipid antibodies.

Findings:

  • The left atrial thrombus was directly linked to antiphospholipid antibodies.
  • The patient was treated with anticoagulation therapy.
  • Serial imaging demonstrated complete resolution of the thrombus over six months.

Implications:

  • This case highlights the potential for Mycoplasma pneumoniae to induce aPL-mediated thrombosis in children.
  • Early diagnosis and anticoagulation are crucial for managing cardiac thrombi in this context.
  • Further research may explore the mechanisms linking Mycoplasma pneumoniae to aPL syndrome.

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