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Published on: September 1, 2019
SRC-3/AIB1: transcriptional coactivator in oncogenesis
Jun Yan1, Sophia Y Tsai, Ming-Jer Tsai
1Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
Acta Pharmacologica Sinica
|March 17, 2006
Summary
Steroid receptor coactivator-3 (SRC-3) is linked to various cancers. Recent findings highlight its causal role in human cancer development and its importance in both hormone-sensitive and -insensitive cancers.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Steroid receptor coactivator-3 (SRC-3) is located on chromosome 20q12, a region frequently amplified in cancers.
- SRC-3 has been associated with the development of breast, gastric, and prostate cancers.
- While previously implicated as an oncogene, recent evidence suggests SRC-3 plays a causal role in human cancer genesis.
Purpose of the Study:
- To summarize recent evidence on the role of SRC-3 in human cancers.
- To highlight the significance of aberrant SRC-3 expression in both hormone-sensitive and hormone-insensitive cancers.
Main Methods:
- Literature review of recent studies on SRC-3 and cancer.
- Analysis of evidence implicating SRC-3 in cancer development.
- Summary of findings related to SRC-3 expression in various cancer types.
Main Results:
- Aberrant SRC-3 expression is increasingly recognized as a critical factor in human cancer.
- SRC-3's role extends to both hormone-sensitive and hormone-insensitive cancer types.
- Compelling evidence now supports SRC-3 as a causal factor in cancer genesis.
Conclusions:
- Aberrant SRC-3 expression is a significant factor in the development of multiple human cancers.
- SRC-3 is important in both hormone-sensitive and hormone-insensitive cancers, underscoring its broad oncogenic potential.
- Further research into SRC-3's mechanisms may reveal new therapeutic targets for cancer treatment.
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