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Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
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Published on: May 11, 2018

[The antigenic properties of hepatitis A virus particles possessing different physicochemical characteristics]

Iu Iu Kusov, T A Nastashenko, Iu A Kazachkov

    Voprosy Virusologii
    |May 1, 1991
    PubMed

    A modified enzyme immunoassay based on adsorption of antihepatitis A virus (HAV) IgG-HRPO conjugate and monoclonal antibodies to HAV were used to investigate antigenic differences between mature HAV virions and subviral particles with different buoyant densities in CsCl produced in HAV-infected cells. The mature virions (1.34 g/cm3) appeared to have common antigenic determinants with subviral particles (1.20, 1.27, and 1.30 g/cm3) and possess some additional determinants. Nevertheless, both subviral particles and mature virions induced antibodies capable of neutralizing HAV infectivity in tissue culture.

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