Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Animal cell shape changes and gene expression.

A Ben-Ze'ev1

  • 1Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A point mutation in the extracellular domain of L1 blocks its capacity to confer metastasis in colon cancer cells via CD10.

Oncogene·2016
Same author

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression.

Oncogene·2015
Same author

Global analysis of L1-transcriptomes identified IGFBP-2 as a target of ezrin and NF-κB signaling that promotes colon cancer progression.

Oncogene·2012
Same author

Nuclear localization of beta-catenin and plakoglobin in primary and metastatic human colonic carcinomas, colonic adenomas, and normal colon.

International journal of surgical pathology·2003
Same author

Down-regulation of beta-catenin by activated p53.

Molecular and cellular biology·2001
Same author

De novo formation of focal complex-like structures in host cells by invading Streptococci.

Molecular microbiology·2001

The cytoskeleton influences cell shape and gene expression by linking to cell surface receptors and signaling pathways. This connection allows external signals to alter cell structure and potentially regulate genetic activity.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell shape and contacts depend on cytoskeleton connections to extracellular matrix and cell surface ligands.
  • Adherens junctions link microfilaments to the membrane, housing regulatory molecules for signal transduction and gene regulation.

Purpose of the Study:

  • To investigate the role of the cytoskeleton in mediating cellular responses to external stimuli.
  • To explore the connection between the phosphoinositide signaling pathway and cytoskeletal regulation of gene expression.

Main Methods:

  • Stimulation of cells with soluble polypeptide factors.
  • Analysis of changes in cell shape and microfilament organization.
  • Investigation of the phosphoinositide signaling pathway activation.

Related Experiment Videos

  • Examination of the linkage between actin-binding proteins and the phosphoinositide pathway.

    • Main Results:

    • Cell stimulation by polypeptide factors induced rapid changes in cell shape and microfilament organization.
    • The phosphoinositide signaling pathway was activated upon cell stimulation.
    • A novel linkage was discovered between actin-binding proteins and the phosphoinositide signaling pathway.

    Conclusions:

    • The cytoskeleton may regulate gene expression through its association with second messenger systems.
    • Localization of regulatory molecules by the cytoskeleton could play a role in gene expression control.
    • Cytoskeletal dynamics are intricately linked to cellular signaling and gene regulation.