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Related Experiment Videos

A small amount of inhaled nitric oxide does not increase lung diffusing capacity.

G S Zavorsky1, J M Murias

  • 1Dept of Anesthesia, McGill University Health Center, Montreal General Hospital, 1650 Cedar Avenue, Room D10-144, Montreal, Quebec H3G 1A4, Canada. gerald.zavorsky@mcgill.ca

The European Respiratory Journal
|March 17, 2006
PubMed
Summary

Inhaled nitric oxide (NO) does not affect lung diffusing capacity for NO or carbon monoxide. Two properly performed trials are sufficient for accurate measurements of lung diffusing capacity and pulmonary capillary blood volume.

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Area of Science:

  • Pulmonary physiology
  • Respiratory medicine
  • Cardiopulmonary function testing

Background:

  • The single-breath method is commonly used to assess lung diffusing capacity.
  • Nitric oxide (NO) plays a role in pulmonary vasodilation and has been investigated for its effects on lung function.
  • Understanding the impact of NO on diffusing capacity measurements is crucial for accurate clinical interpretation.

Purpose of the Study:

  • To investigate the effect of inhaled nitric oxide (NO) on lung diffusing capacity for NO (D(L,NO)) and carbon monoxide (D(L,CO)).
  • To determine the optimal number of single-breath tests for reliable estimation of D(L,NO), D(L,CO), membrane diffusing capacity for CO (D(m,CO)), and pulmonary capillary blood volume (V(c)).
  • To assess the repeatability of these pulmonary function parameters using the single-breath D(L,NO)-D(L,CO) method.

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Main Methods:

  • 31 healthy subjects performed five sequential single-breath hold maneuvers at rest.
  • Subjects inhaled a mixture containing 40-50 ppm nitric oxide (NO) and a standard diffusion mixture.
  • Lung diffusing capacity for NO (D(L,NO)), carbon monoxide (D(L,CO)), membrane diffusing capacity for CO (D(m,CO)), and pulmonary capillary blood volume (V(c)) were measured.

Main Results:

  • Inhaled nitric oxide (NO) did not alter D(L,NO) or D(m,CO) across the five trials.
  • D(L,CO) and V(c) showed significant decreases from the first trial by the fourth and third trials, respectively.
  • Repeatability over five trials was 17 mL.min(-1).mmHg(-1) for D(L,NO), 3 mL.min(-1).mmHg(-1) for D(L,CO), 7 mL.min(-1).mmHg(-1) for D(m,CO), and 13 mL for V(c).

Conclusions:

  • Inhaled nitric oxide (NO) does not impact D(L,NO) or D(m,CO) during sequential single-breath maneuvers.
  • Performing more than two trials can reduce the accuracy of V(c) and D(L,CO) measurements.
  • The study recommends using the average value from two properly executed single-breath trials for reliable pulmonary function assessment.